Premature menopause has been described as a diagnosis that changes life with deep physical, psychological and social consequences. Affected women not only experience the effects of estrogen deficiency, but also experience unforeseen loss of reproductive function. However, some women are more affected by these changes than others. A new study helps explore the reasons for these differences. The results are published on July 16 in MenopauseThe Journal of the Menopause Society.
Premature menopause, medically known as premature or primary ovarian insufficiency (POI), is a condition in which ovaries stop working normally before the age of 40. It has been related to a high risk of depression and anxiety. A recent meta -analysis revealed an ODDS ratio of 3.3 for depression and 4.9 for anxiety in women with POI compared to those who do not have the condition. The greatest risk is understandable given the combined experience of infertility and additional loads resulting from estrogen deficiency, such as stifling, vaginal dryness, reduced bone mineral density and a greater risk of cardiovascular disease, among others. For some women, infertility means altered life objectives, loss of sense of control, social stigma and interrupted social roles.
However, not all women experience depression or the same level of depression when they occur with the same diagnosis. In this new study, the researchers gathered data from almost 350 women with POI to try to identify the specific variables that contribute to the probability of depressive symptoms. His first observation was the high prevalence of depression among the participants. Almost a third (29.9%) of women with POI suffered depressive symptoms.
The researchers also found that a younger age in the diagnosis of POI, the severe symptoms of menopause, the pain related to fertility and lack of emotional support were risk factors. No significant differences were found in depressive symptoms between women who use estrogen plus progestogen therapy and those who do not use hormonal therapy, underlining the role of psychosocial factors. Interestingly, a genetic cause of Poi was associated with lower depressive symptoms. Another unexpected result was that, although a greater burden of the symptoms of menopause was associated independently with depressive symptoms, the suffocations (specifically night sweats) were not.
This is the first known large -scale study that investigates specific variables associated with depressive symptoms in women with POI. Researchers believe that their results highlight the importance of comprehensive care that address the physical and psychological aspects of menopause at an early age.
The survey results are published in the article “Depressive symptoms in women with premature ovarian insufficiency (POI): a cross -sectional study.”
“The high prevalence of depressive symptoms in those with POI highlights the importance of routine detection in this vulnerable population. Although hormonal therapy is recognized as the standard of attention for those with POI for the handling of some symptoms related to menopause and preventive attention, the first -line treatment for mood disorders. This was evident in this study in which there were no differences in depressive symptoms between Those who use hormones and do not go to those who do not go to those who do not direct tormas.
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