
G-quadruplexes reveal molecular links between telomeres and telomerase: critical findings for neoplastic transformation, aging and regenerative therapy
Normal cells age and eventually die when they have reached their maximum useful life. In these cells, telomeres, the end of a chromosome, cannot be synthesized due to the suppression of the inverse transcriptase enzyme of human telomerase (HTERT), resulting in the shortening of telomeres. Although the link is not clear yet, many studies showed…